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In this paper we report the synthesis of metamaterial transmission lines by means of aggressive space mapping (ASM). Specifically, it is demonstrated that ASM can be applied to the automated layout generation of composite right/left handed (CRLH) microstrip lines based on a combination of complementary split ring resonators (CSRRs) and series gaps. To illustrate the potentiality and accuracy of the approach, we report in this work the synthesis of a CRLH line. This work represents a clear progress on the synthesis of CSRR-based artificial lines, since we are now able to synthesize structures with a combination of CSRRs and series capacitances. These structures exhibit a CRLH behavior of great interest in microwave engineering to implement enhanced bandwidth components, multi-band devices, or compact filters, among others. Therefore, the reported approach will have a direct impact in reducing the efforts for designing these metamaterial based planar components.