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Robust control approach to force estimation in a constant position optical tweezers

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3 Author(s)
Aggarwal, Tanuj ; University of Minnesota, 200 Union St SE, Minneapolis, Minnesota 55455, USA ; Sehgal, H. ; Salapaka, M.

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Feedback enhanced optical tweezers with position regulation capability enable detection and estimation of forces in the pico-Newton regime. In this article we delineate the fundamental limitations and challenges of existing approaches for regulating position and force estimation in an optical tweezer. A modern control systems approach is shown to improve the bandwidth of force estimation by three to four times which is corroborated experimentally.

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Review of Scientific Instruments  (Volume:82 ,  Issue: 11 )