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Existing ESB is congested when different types of business flows compete for limited resources. To solve this problem, a real-time ESB model is proposed. The JBI specification was modified, business priority and time restriction semantic were added, together with flow control and bandwidth allocation modules. This system can dynamically allocate the system bandwidth from high to low priority business type at runtime according to bandwidth demand. A simulation environment was built based on regional medical information exchange platform. The simulation results demonstrated that this method can guarantee the bandwidth for high-priority business flows, reduce the congestion and decline of quality of services, thus improve overall system throughput.