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This paper presents a low-voltage and low-power Programmable Gain Amplifier (PGA) designed in a 0.18μm CMOS process, which is applied in Wireless Sensor Network (WSN). To achieve high gain range and linearity performance, multi-stage cascade based on gm-boosted differential pair with degenerated resistor and fully-differential resistive feedback topology is used. AC coupling is utilized to eliminate the DC offset due to its stability, low power and easy to implement. The voltage gain of this PGA can be changed from 0dB to 70dB with 2dB step. The -3dB bandwidth is larger than 11MHz at the highest gain. The current consumption is only 1.9mA with a supply voltage of IV.