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Design and fabrication of a novel resonant surface sensitive to out-of-plane forces for the indentation and injection of living cells

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3 Author(s)
Denis Desmaële ; CEA, LIST, Sensory and Ambient Interfaces Laboratory, 18 Route du Panorama, BP6, Fontenay-aux-Roses, F-92265, France ; Mehdi Boukallel ; Stéphane Régnier

We present a novel force sensor for cell indentation and cell injection. This force sensor is a monolithic structure that integrates two resonators. It provides a surface sensitive to out-of-plane forces where a living cell can be conveniently placed for manipulation. Normal forces applied upon the cell under study are estimated via frequency shifts of the resonators. In this paper, we develop a theoretical study for predicting and optimizing the structure's sensitivity. As a proof of concept, we also report the fabrication and experimental characterization of a first prototype. In ambient conditions, our prototype presently offers a quality factor of ~700, and a linear sensitivity of ~5.75 Hz/??m. In addition, we report the implementation of a compact and low-cost optical fiber setup to monitor the resonators' frequency. Potential applications are illustrated with the measurement of forces applied on lobster eggs.

Published in:

2011 IEEE/RSJ International Conference on Intelligent Robots and Systems

Date of Conference:

25-30 Sept. 2011