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The performance mismatch between computing and I/O components of current-generation HPC systems has made I/O the critical bottleneck for scientific applications. It is therefore critical to make data movement as efficient as possible, and, to facilitate simulation-time data analysis and visualization to reduce the data written to storage. These will be of paramount importance to enabling us to glean novel insights from simulations. We present our work in GLEAN, a flexible framework for data-analysis and I/O acceleration at extreme scale. GLEAN leverages the data semantics of applications, and fully exploits the diverse system topologies and characteristics. We discuss the performance of GLEAN for simulation-time analysis and I/O acceleration with simulations at scale on leadership class systems.