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The paper describes an estimation method of path-loss for capsule endoscopy using wireless communications to send images from digestive tract. This method is based on the use of a set of X-ray computer tomography (CT) images of the patient. In order to evaluate this method, we conducted a measurement of received signal strength (RSS) by introducing a signal generator (SG) in esophagus and duodenum of a participant. As a result of comparisons, the method provides estimates on path-loss for the participant with estimation errors of less than 6 dB in 75% measurement positions.