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A new tool has been developed for comparison and evaluation of medical images based on image registration and edge detection algorithms. The tool performance has been demonstrated on the processing of the ortopantomograms taken before and after treatment. The accuracy of the performance has been discussed and the possible origins of tool performance errors have been explained. The results obtained using presented tool have been discussed by an expert. The expert has confirmed that the tool is well suited for comparison and evaluation of ortopantomograms. The expert has come to the conclusion that our tool can be useful in other specializations of dentistry, not only in orthodontics.