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In this letter, a high-speed full-duplex indoor optical wireless communication system for both down-link and up-link is experimentally demonstrated. The feasibility of simultaneous error-free (bit-error-rate or BER <; 10-9) operation of both a 10-Gbps down-link and a 500-Mbps up-link with a beam footprint of ~1 m has been demonstrated. Negligible power penalty due to the crosstalk is observed. When this full-duplex system is incorporated with our recently proposed novel optical wireless localization system, error-free operation can be provided over the entire room.