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Adaptive antenna arrays at both the base and mobile stations can further increase system capacity and improve the quality of service of conventional orthogonal frequency division multiplexing (OFDM) systems. Conventional adaptive antenna array-based multiple-input multiple-output (MIMO)/OFDM systems use the sub-carriers characterized by the largest eigenvalue to transmit the OFDM symbols. This paper describes the performance of adaptive subchannel assignment-based MIMO/OFDM systems over multipath fading channels. The system adaptively selects the eigenvectors associated with the relatively large subchannel eigenvalues to generate the antenna array weights at the base and mobile stations and then adaptively assigns the corresponding best subchannels to transmit the OFDM symbols. Simulation results show that the proposed system can achieve better performance than the conventional adaptive antenna arraybased MIMO/OFDM system over multipath fading channels.