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Interaction of stathmin-like 2 protein with the APP intracellular domain

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7 Author(s)
Li, Zhidong ; State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China ; Wang, Weiwei ; Zhou, Fangfang ; Gao, Xia
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Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer's disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.

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Tsinghua Science and Technology  (Volume:10 ,  Issue: 4 )