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Effect of new O-superfamily conotoxin on voltage-activated currents of hippocampal neurons

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5 Author(s)
Li, Zhan ; Department of Biological Sciences and Technology, Tsinghua University, Beijing 100084, China ; He, Xiangping ; Dai, Qiuyun ; Huang, Peitang
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The effects of a new O-superfamily conotoxin, S03, on sodium current (INa), transient A-type potassium currents (IA), and delayed rectified potassium currents (IK), were examined in cultured rat hippocampal neurons using the whole-cell patch clamp technique. Addition of S03 caused a concentration-dependent, rapidly developing, and reversible inhibition of voltage-activated currents. The IC50 values for the blockage of INa, IA; and IK were calculated as 0.49, 33.9, and 7.6 μmol/l., respectively. The determined Hill coefficients were 1.7, 0.6, and 1.2, respectively. These results indicate that S03 can selectively inhibit neuronal sodium and potassium currents.

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Tsinghua Science and Technology  (Volume:9 ,  Issue: 1 )