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Gene disease diagnostic system

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9 Author(s)
Guoliang Huang ; Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; Beijing National Biochip Research and Engineering Center, Beijing 100084, China; Capital Biochip Corporation, Beijing 100084, China ; Tengfei Zhang ; Jing Cheng ; Yuxiang Zhou
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Binary optics, where the optical element can be fabricated on a thin glass plate with micro-ion-etching film layer, has been widely applied in recent years. A novel optical scanning system for gene disease diagnostics described in this paper has four kinds of optical devices, including beam splitters, an array lens, an array filter and detection arrays. A software was developed to design the binary optics system using an iterative method. Two beam splitters were designed and fabricated, which can divide a beam into a 9 × 9 array or into a 13 × 13 array. The beam splitters have good diffraction efficiencies (>70%) and an even energy distribution. The gene disease diagnostic system is a portable biochip and binary optics technology. The binary optical devices in the non-confocal scanning system can raise the fluorescence detection sensitivity of the micro-array hybrid biochip.

Published in:

Tsinghua Science and Technology  (Volume:7 ,  Issue: 6 )