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This letter presents two preprocessing techniques for narrow-band interference (NBI) rejection in Time-Division-Duplex (TDD) CDMA systems. In the proposed methods, at the transmitter, by using Karhaunen-Loeve Transform and Discrete Fourier Transform, the transmitted power is set to zero in the directions of the eigenvectors that will be severely contaminated by NBI; and therefore less part of the transmitted energy will be polluted by NBI in channel. The processing is transferred from receiver to transmitter, and thus the complexity of the receiver is significantly reduced. It is assumed that channel state information can be estimated at the transmitter because in symmetric TDD systems each receiver in turn also acts as a transmitter.