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Two adaptive power and bit loading algorithms to maximize the throughput of MIMO-OFDM systems in frequency selective fading environment are proposed. The two algorithms allocate bit based on maximizing the overall throughput. One algorithm allocates power based on guaranteeing that the bit error rate (BER) of each sub-carrier and the total allocated power remain below a target BER threshold and a power threshold, respectively; another one allocates power based on guaranteeing that the mean BER of sub-carriers and the total allocated power remain below a target BER threshold and a power threshold, respectively. The simulation results show that the proposed algorithms can achieve faster throughput with lower computational complexity, which indicates that the proposed algorithms are effective when compared to some existing algorithms.