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The structure and performance of space-time multiuser detection receiver at base stationsof WCDMA system is analyzed, in which smart antenna is employed. WCDMA uplink signal model is established in this paper. Space-time multiuser receiver presented in this paper combines 2D-RAKE with parallel interference cancellation(PIC), and the improved parallel interference cancellation methods are given. A novel space-time multiuser detection scheme, 2DRAKE-GPPIC is proposed. This scheme employs smart antenna to suppress unexpected DOA (Direction Of Arrival) signal, uses RAKE receiver to combine different delays of expected signal, and utilizes grouped partial parallel interference cancellation (GPPIC) algorithm to suppress further the interference signal in the main lobe of array antennas. The simulation results reveal that the scheme of space-time multiuser detection presented in this paper has better performance for WCDMA system.