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Novel manufacturing processes and machine designs can be developed by means of mechatronic modules and their adaptation to the specific manufacturing case. The complexity of these modules must be carefully chosen so that a reuse for different application processes becomes possible. If a mechatronic module is too specific or complex, it cannot be engaged for other machine designs, as it is made only for that specific case. The methodology of axiomatic design is introduced and adapted towards the engineering of mechatronic modules in machine development for special manufacturing processes. The presented approach of systematic modular design allows for the engineering of mechatronic modules and the identification of the required links between modules.