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Flexibility has long been recognized as a manufacturing capability that has the potential to impact mainly the competitive position of an organization. The entropy approach, which was extended from information theory, fell in handling problems with incomplete and uncertain data, because it depicts only the stochastic aspects included with measured observations. In order to get a global view, this work proposes a new approach based on fuzzy entropy concept. The development of the fuzzy model results in a set of nonlinear constrained problems to be solved using a metaheuristics method. The applicability of our approach is illustrated through a flexible manufacturing cell. By adopting such framework, both dimensions of uncertainty in system modeling, expressed by stochastic variability and imprecision, can be taken into consideration.