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We studied on microbial activity in wetland soils of dry lake of Hui Teng xi le in semi-arid steppe with the reference of typical steppe in semi-arid areas. Microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), basal respiration (BR), potential respiration (PR), microbial quotient (qMB), and metabolic quotient (qCO2) of soils were used to survey microbial activity . The results showed that: in the successive process of recession in dry lake the soil microbial activity characteristics in wetland tend towards the landward distribution: soil microbial biomass carbon (SMB-C) was the lake bed(HD)<; the lake center(HX)<;the lake side(HB)<;the typical steppe(DT); Microbial biomass nitrogen (SMB-N) was HX<;HD<;HB<;DT; Basal respiration was DT<;HB<;HD<;HX; Potential respiration(PR) was DT<;HD<;HB<;HX; Microbial quotient(qMB) was in 0.7% ~ 1.3%, HD<; HB <; HX <; DT; Microbial metabolic quotient (qCO2) is DT <;HB<;HX <;HD. We consider that degradation of dry lakes was in the process of evolution; soil microbial activity in this wetland was still in the relatively unstable interference phase.