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Spectral analysis of a thalamus-to-cortex seizure pathway

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5 Author(s)
Sherman, D.L. ; Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA ; Yien Che Tsai ; Rossell, L.A. ; Mirski, M.A.
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Physiological evidence has shown that the anterior thalamus (AN) and its associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic clonic epileptic seizures. In this study the authors extend and confirm the support for AN's role by examining neuro-electric signal indicators during seizure episodes. They show that the electroencephalogram (EEG) recorded from AN is highly coherent with the EEG derived from the cortex (CTX). By removing the effects of another thalamic nucleus, posterior thalamus (PT)-unaffiliated with the tract linking AN to cortex-partial coherence analysis leaves the CTX/AN coherence undiminished. The most robust band of strong CTX-AN coherence is centered around the spike wave pacing frequency of 1-3 Hz. Partial-multiple coherence analysis techniques are used to remove the possible signal contributions from hippocampus in addition to PT. The CTX-AN coherence still remains undiminished in the low-frequency bands. Conclusive evidence from coherence studies and other spectral measures reaffirm the special role of the AN in the propagation of seizure activity from subcortex to cortex.

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Biomedical Engineering, IEEE Transactions on  (Volume:44 ,  Issue: 8 )