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In light of such overwhelming interest from governments and academia in adopting and advancing IT for effective healthcare, there are great opportunities for researchers and practitioners alike to invest efforts in conducting innovative and high-impact healthcare IT research. This IEEE Intelligent Systems Trends and Controversies (T&C) Department hopes to raise awareness and highlight selected recent research that helps move us toward such goals. This department includes three articles on Smart Health and Wellbeing from distinguished experts in computer science, information systems, and medicine. Each article presents unique perspectives, advanced computational methods, and selected results and examples.