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A high-throughput biosensor for detection and quantification of protein induced DNA bending

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5 Author(s)
Xirui Zhang ; Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA ; Spuhler, P. ; Unlu, M.S. ; Sola, L.
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The functions of genes depend on interactions with DNA-binding proteins. DNA bends or kinks upon specific binding with proteins. This biosensor measures binding-induced conformational changes of DNA in a high-throughput manner with sub-nanometer accuracy.

Published in:

Optical MEMS and Nanophotonics (OMN), 2011 International Conference on

Date of Conference:

8-11 Aug. 2011