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Understanding centrality-lethality rule in yeast Protein-Protein Interaction network by topological property

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4 Author(s)
Dong Yun-Yuan ; Sch. of Comput., Nat. Univ. of Defense Technol., Changsha, China ; Wang Zheng-Hua ; Liu Qi-Jun ; Wang Yong-xian

One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.

Published in:

Information Technology and Artificial Intelligence Conference (ITAIC), 2011 6th IEEE Joint International  (Volume:2 )

Date of Conference:

20-22 Aug. 2011