Scheduled System Maintenance:
On May 6th, single article purchases and IEEE account management will be unavailable from 8:00 AM - 12:00 PM ET (12:00 - 16:00 UTC). We apologize for the inconvenience.
By Topic

Understanding centrality-lethality rule in yeast Protein-Protein Interaction network by topological property

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Dong Yun-Yuan ; Sch. of Comput., Nat. Univ. of Defense Technol., Changsha, China ; Wang Zheng-Hua ; Liu Qi-Jun ; Wang Yong-xian

One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.

Published in:

Information Technology and Artificial Intelligence Conference (ITAIC), 2011 6th IEEE Joint International  (Volume:2 )

Date of Conference:

20-22 Aug. 2011