By Topic

Anti-nociceptive effects of DAACS water extract

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Zhou Xiaoqiu ; Campus Hosp., Beihua Univ., Jilin, China ; Zhang Min

Direct reflux and TLC methods were used to isolate and identify de-aristolochic acid Aristolochia tuberosa C. F. Liang et S. M. Hwang (DAACS). Different doses of DAACS were administered intragastricly (i.g) and methods of hotplate, writhing, hot-bathing and tail-flick method were used to observe anti-nociceptive effects of DAACS; β-Endorphin (β-EP) and prostaglandin E2 (PGE2) contents of mice were detected with radioimmunoassay (RIA) to explore the anti-nociceptive mechanisms of DAACS. The results showed that DAACS (0.4, 0.8, 1.6 g·kg-1) could prolong mice' responsive latencies to hotplate significantly compared with those in the control group, delay writhing latencies of mice and reduce their writhing times, delay tail-flick latencies of mice, and reduce contents of β-EP in brain and PGE2 in liver tissue of formalin-treated mice significantly. DAACS would produce anti-nociceptive effects and its anti-nociceptive mechanism may be related to its effect on β-EP in brain and PGE2 in liver tissue of mice.

Published in:

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Date of Conference:

19-22 Aug. 2011