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Through theoretical analysis and experimental study, this paper discusses the key issues in the wireless capsule endoscopy MEMS system, such as the optics design, the image capturing, the transmitter, the power supply and so on. The reasonable design of lens and lens holder insures imaging of the system; An illumination device is designed according to the imaging illuminance of the image sensor in the capsule; The system circuit is controllable in the wireless way outside the body through the magnetic switch and a magnetic field array, so that the point checking can be carried out. All the parameters and configurations of the endoscope system prototype are designed with the principles of micromation and low power consumption. The images captured by the capsule in live animal experiments indicate that the miniature wireless capsule endoscopy is feasible.