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The local protein-protein interactional feature can be caught by machine-learning method

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4 Author(s)
Tienan Feng ; Dept. of Math., Shanghai Univ., Shanghai, China ; Liang Da ; Dingli Jin ; Yifei Wang

Protein-protein interactions (PPIs) are central for most biological processes. Much effort has been put into the development of methodology for predicting PPIs and the construction of PPIs networks. Though a high accurate rate those methods have achieved, it was found that the accurate rate strongly depends on the balance of datasets. Compare to negative datasets, positive datasets contain some proteins which are called hub protein intact more proteins. And the unbalance between datasets leads to an excellent performance of PPIs prediction. But when one used balance datasets, the performance is disappointed. Different Biological functions are supported by different local PPIs network. Does it mean that local PPIs network has its own feature? In this paper, we managed to catch features of local networks in three species on the condition that there is no unbalance between positive dataset and negative dataset. Features of local PPIs network fades as the network extended. The associate rules method is used to analyze features of local PPI network. All the datasets used in this study are derived from public available database.

Published in:

Fuzzy Systems and Knowledge Discovery (FSKD), 2011 Eighth International Conference on  (Volume:3 )

Date of Conference:

26-28 July 2011