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We present a new surface acoustic wave (SAW) chip for odorant detection by the using of olfactory receptors as molecular sensors. The molecular sensors were originated from the expression of ODR-10 in human breast cancer MCF-7 cells, which is an olfactory receptor of C. elegances. ODR-10 was then combined with SAW chips to serve as molecular sensors for odorant detection. The resonance frequency shifts of SAW can be recorded to characterize the responses of this molecular sensor to various odorants. The recording data show this molecular sensor can recognize its natural ligand of diacetyl with high specificity and sensitivity. It is indicated that this molecular sensor has great potential to be applied in many fields such as biomedicine, environmental monitoring, and food quality control.