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Information Systems are needed for modernization of ICUs to deliver better health care services. EHR systems can improve the work flow management in health care delivery. This work proposes a secure web enabled system based on a multi-tier architecture for carrying out routine and special operations of Neonatal Intensive Care Unit (NICU). The system adopts a service oriented approach for execution of various tasks that are performed for managing NICU activities. It also facilitates decision support systems for a number of critical tasks of NICU. A prototype of the system has been installed in the neonatology department of SSKM Hospital, Kolkata, India and the staff of the hospital including doctors, nurses, laboratory personals and technicians are using it in a regular manner.