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While CUDA and OpenCL made general-purpose programming for Graphics Processing Units (GPU) popular, using these programming approaches remains complex and error-prone because they lack high-level abstractions. The especially challenging systems with multiple GPU are not addressed at all by these low-level programming models. We propose SkelCL - a library providing so-called algorithmic skeletons that capture recurring patterns of parallel computation and communication, together with an abstract vector data type and constructs for specifying data distribution. We demonstrate that SkelCL greatly simplifies programming GPU systems. We report the competitive performance results of SkelCL using both a simple Mandelbrot set computation and an industrial-strength medical imaging application. Because the library is implemented using OpenCL, it is portable across GPU hardware of different vendors.