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In this paper, we deal with low-complexity near-optimal detection/equalization in large-dimension multiple-input multiple-output inter-symbol interference (MIMO-ISI) channels using message passing on graphical models. A key contribution in the paper is the demonstration that near-optimal performance in MIMO-ISI channels with large dimensions can be achieved at low complexities through simple yet effective simplifications/approximations, although the graphical models that represent MIMO-ISI channels are fully/densely connected (loopy graphs). These include 1) use of Markov random field (MRF)-based graphical model with pairwise interaction, in conjunction with message damping, and 2) use of factor graph (FG)-based graphical model with Gaussian approximation of interference (GAI). The per-symbol complexities are O(K2nt2) and O(Knt) for the MRF and the FG with GAI approaches, respectively, where K and nt denote the number of channel uses per frame, and number of transmit antennas, respectively. These low-complexities are quite attractive for large dimensions, i.e., for large Knt. From a performance perspective, these algorithms are even more interesting in large-dimensions since they achieve increasingly closer to optimum detection performance for increasing Knt. Also, we show that these message passing algorithms can be used in an iterative manner with local neighborhood search algorithms to improve the reliability/performance of M-QAM symbol detection.