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This review evaluates example technologies from the point-of-view of likely translation into human use, including regulatory clearance, insertion into common medical practice and reimbursability. The intent is to highlight recent innovations in implantable sensors with a focus on the translational process itself in a holistic fashion. As well as looking at success stories, this review will also examine several seemingly promising technologies that have failed for reasons having nothing to do with the operational aspects of the sensors and systems involved. Innovation must be viewed as a multifaceted process, all segments of which must be fully addressed to achieve success. No party to the process can work in isolation and expect to achieve the end goal of providing new advances to patients. This review will have succeeded if it provides the reader with a better appreciation of the complex environment in which implantable sensor discoveries that seek to be translated into human medicine must navigate.