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The outage performance of dual-hop decode-and-forward relaying systems with multiple co-channel interferers at both nodes, namely relay and destination, and subject to arbitrary Nakagami-m fading is investigated. More specifically, an indeed highly accurate closed-form approximate expression for the end-to-end outage probability is derived that is simple to calculate and yields results instantaneously independently of the number of interferers, thus circumventing the intricacy and the computationally inefficiency of the exact formulation. Simulation results are shown that corroborate the tightness of the proposed approximations. It is noteworthy that the results apply to general operating scenarios with distinct, non-integer Nakagami-m fading parameters and unequal average fading powers between hops.