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Cyber Physical System is the most popular information technology at the present. In this paper, the monitoring systems and information systems are integrated deeply, CPS architecture is introduced high-speed Railway Safety Comprehensive Monitor and Control System, under analysing and the guidance of the classical architecture, a four structure of CPS architecture is proposed to solve the problems of system which faces the heterogeneity of networks, the complexity of platforms, the diversity of protocols, dispersity of the data and so on. The paper discusses the key technologies of system such as the real-time monitor technique, dynamic matching technique and the Cyber Physical System-Internet Protocol technique. Finally, the paper put forward some future research work of the system.