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Regional cleaner production is an important embodiment of circular economy in regional level. B/S structure is defined as a new network management information system platform on the basis of the web technology. This paper attempts to explore the design of information management system on regional cleaner production. There are 4 functional modules, including user management, management of cleaner production information in enterprises and industries, and information announcements. The information management system on regional cleaner production combines information management of cleaner production in regional industries with that in enterprises, in order to possess the functions of aiding the adjustment of regional industry structure, cleaner production audits in enterprises, and continuous cleaner production. This system is an effective tool for information management on regional cleaner production and decision aids, as well as exerts a key role in promoting the construction of circular economy.