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A fully-integrated cantilever-based DNA detection SoC in a CMOS Bio-MEMS process

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14 Author(s)
Yu-Jie Huang ; National Taiwan University, Taipei, Taiwan ; Che-Wei Huang ; Tsung-Hsien Lin ; Chih-Ting Lin
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A highly-integrated DNA detection SoC, which includes DNA sensors, readout circuit, MCU, and OOK TX/RX, is implemented in a 0.35μm CMOS Bio-MEMS process. For low DNA concentration, an oscillator-based self-calibrated readout circuit with high sensitivity (2kHz/Ω) is proposed to convert small resistance variation of the piezoresistive cantilever sensor into adequate frequency shift. The measured results reveal that it could detect <;0.02% of resistance variation (0.6Ω) and cover detection concentration range of specific DNA from 100pM to 1μM.

Published in:

VLSI Circuits (VLSIC), 2011 Symposium on

Date of Conference:

15-17 June 2011