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In order to obtain overall optimal solution to folding mechanism, multidisciplinary design optimization technology was applied. According to design requirements of the folding mechanism, working performance, weight and reliability were taken as three important disciplines. The relevant mathematical models were established by using experiment technology, computer simulation technology and response surface method. Share variables, coupling variables and local variables were determined and the corresponding multidisciplinary collaborative design optimization model was set up. The final optimization results prove the feasibility of the proposed method.