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LTI Models for 3-Iodothyronamine Time Dynamics: A Multiscale View

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4 Author(s)
Orsi, G. ; Interdept. Res. Center E. Piaggio, Univ. of Pisa, Pisa, Italy ; Frascarelli, S. ; Zucchi, R. ; Vozzi, G.

3-Iodothyronamine (Tι AM) is a novel relative of thyroid hormone that plays a role in critical body regulatory processes such as glucose metabolism, thermal regulation, and heart beating. This paper was aimed at characterizing time dynamics of T1AM and its catabolite 3-iodothyroacetic acid (TA1) in different biological scales with linear time-invariant models. Culture medium samples coming from culture of H9c2 murine cells and perfusion liquid samples from perfused rat heart were collected after the injection of a T1AM bolus. T1AM and TA1 concentrations in the samples were assayed with high-performance liquid chromatography coupled to tandem mass spectrometry. Kinetic constants relative to T1AM transport and conversion were estimated with weighted least-squares method. We found that these constants can be related with an allometric power law depending on mass, with a negative exponent of -0.27 ± 0.19, implying that the velocity of conversion and internalization of Ti AM decreases with increasing of system mass.

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Biomedical Engineering, IEEE Transactions on  (Volume:58 ,  Issue: 12 )