Cart (Loading....) | Create Account
Close category search window
 

A ns-μs duration, millitesla, exponential decay pulsed magnetic fields generator for tumor treatment

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

7 Author(s)
Yan Mi ; State Key Lab. of Power Transm. Equip. & Syst. Security & New Technol., Chongqing Univ., Chongqing, China ; Chenguo Yao ; Chun Jiang ; Chengxiang Li
more authors

In order to research a new tumor treatment method using exponential decay pulsed magnetic fields (EDPMF), we developed a EDPMF generator by means of the integration of pulsed power technology and modern power electronics technology. After charging a capacitor with a high voltage dc power supply, EDPMF was generated inside the Helmholtz coils by means of discharging the capacitor through a switch to the discharge resistor. After a brief introduction of basic principle of EDPMF generator, steep pulse formation circuit and Helmholtz coils, two main parts of EDPMF generator, were discussed in detail, especially on design techniques. A height-adjustable platform was designed inside the Helmholtz coils. Cell solution and little animals could be treated on this platform. The peak value, width and repeat rate of the output EDPMF waveform could be adjusted independently in the range of 0 - 1 mT, 160 ns-55 μs and 1 Hz-1 kHz, respectively. The rise time of the output EDPMF waveform was shortened to 70-220 ns by means of choosing quickly operating switch and reducing circuit stray inductance. Magnetic field distribution uniformity was improved via designing better geometrical structure of Helmholtz coils. This was proved by finite element simulation and measurement. Cell experiment in vitro was performed by exposing human liver cancer cells (Hep-G2) to pulsed magnetic field (0.8 mT, 55 μs, 15 Hz) using this generator and the result showed that proliferation of cancer cells in treated group was significantly (P<;0.01) inhibited. This suggests possible clinical application using this kind of EDPMF for local tumor treatment.

Published in:

Dielectrics and Electrical Insulation, IEEE Transactions on  (Volume:18 ,  Issue: 4 )

Date of Publication:

August 2011

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.