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In Physics of Failure (PoF) based Single-board computer reliability prediction, FMMEA is firstly introduced to get the failure modes, mechanism and physics of failure models. Performance parameters such as material, structure, technology and stress are used to found the simulation model. Some data are acquired by stress analysis and then Probabilistic Physics of Failure (PPoF) models are used to carry out damage analysis, from which a great amount of TTF (the time to failure)samples under single point and single failure mechanism are achieved. Reliability parameters like failure rate and MTBF can be computed through fusing of TTF data. Reliability prediction of a single board computer was given as an example of the failure simulation method. This method links reliability with structure, material and stress of a product, which will assist finding the weakest point of a product and adopting effective measures. This method is a supplement to statistics data based reliability prediction method.