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In this paper, we present a real time biologically motivated 3D motion classifier cells integrating the depth information generated from a stereo input implemented in an active vision system. The proposed approach is accurately able to detect and estimate multiple interfered 3D complex motions under the absence of predefined spatial coherence. Moreover, the system has ability to examine the response of input 3D motion vector fields to a certain 3D motion patterns (3D motion classifier cells) such as motion in the Z direction representing movements towards the system, which is very important to overcome typical problem in autonomous mobile robotic vision such as collision detection and inhibition of the ego-motion defects of a moving camera head. The output of the algorithm is part in a multi-object segmentation approach implemented in an active vision system.