By Topic

The effect of heart motion on kinetic parameter estimates for dynamic cardiac SPECT

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Ross, S.G. ; Dept. of Radiol., Utah Univ., Salt Lake City, UT, USA ; Gullberg, G.T. ; Huesman, R.H.

Dynamic cardiac SPECT is used to estimate kinetic rate parameters that describe the washin and washout of tracer activity between the blood and the myocardial tissue. These kinetic parameters correlate to myocardial perfusion. There are, however, many physical aspects associated with dynamic SPECT which introduce bias and variance into the estimates. This paper describes a study which investigates the effect of heart motion on kinetic parameter estimates. Dynamic SPECT simulations are performed using a beating version of the MCAT phantom. The amount of blood and background activity in the myocardial tissue regions of interest is shown to vary over the cardiac cycle causing errors in the kinetic parameter estimates, particularly estimates of the washin rate constant. The effect of cardiac motion on kinetic parameter estimates is reduced by bias and variance introduced by photon noise and geometric collimator response. This suggests that techniques used to correct for motion must do so without further reducing photon statistics

Published in:

Nuclear Science, IEEE Transactions on  (Volume:44 ,  Issue: 3 )