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In-situ generation and shrinkage of monodisperse water-in-oil emulsion for femtoliter compartmentalization using capillary traps

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3 Author(s)
Wu, Tianzhun ; Sch. of Phys. & Eng., Sun Yat-sen Univ., Guangzhou, China ; Suzuki, Hiroaki ; Yomo, Tetsuya

A novel, facile and effective microfluidic approach to achieve monodisperse femtoliter (fL, 10-15L) water-in-oil (W/O) droplet array is proposed for constructing artificial cell-sized micro reactors. By combining the controlled diffusion of water into oil and capillary-based 2D micro trap array (capillary traps), in-situ generation and 1000-fold volume shrinkage down to ~4 fL have been achieved for monodisperse W/O array. With improved 3D trap array, high-density and well-aligned fL W/O droplet array with good long-time stability and coefficient of variation (CV) smaller than 5% has also been demonstrated. This approach also enables dynamically tuning of droplet sizes and solution concentration useful for many applications.

Published in:

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Date of Conference:

5-9 June 2011