Multimodal bio - image sensor for real - time proton and fluorescence imaging

A multimodal bio-image sensor for proton (pH, power of Hydrogen) and filter-less fluorescence imaging is developed, and its prototype has been fabricated using CMOS silicon integrated circuit technology. Both pH and fluorescence images were successfully obtained without optical filters or gratings and simultaneously in the same area in real time using the developed image sensor for the first time. In the developed device, a pH sensor which uses CCD image sensor technology and a filter-less fluorescence detection sensor are fused in the same pixel.