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Gold nanoparticles immobilized quartz crystal microbalance biochip with ultrasonic standing wave enhancement for real-time sensing protein-ligand interaction

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2 Author(s)
Guo-Hua Feng ; Dept. of Mech. Eng., Nat. Chung Cheng Univ., Chiayi, Taiwan ; Shu-Xiang Yang

This study presents a novel biochip containing a gold-nanoparticles modified quartz crystal microbalance (nano-Au-QCM) sensor and a piezoelectric transducer which enhances performance by production of ultrasonic standing waves (USW). Biotin-streptavidin binding is used as a model in experiments with the developed biochip to verify that nano-Au-QCM and USW enhancement greatly improves biochip detection sensitivity (~2-fold) and reduces detection time (~50%) by increasing the effective analyte concentration. The presented design shows good promise for development into a practical commercial system for enhanced real-time in situ detection of protein-ligand interactions in medical and pharmaceutical applications.

Published in:

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Date of Conference:

5-9 June 2011