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This paper reports about the latest instrumentation technique of Gene Expression using DNA Microarray. DNA Microarray Image Analysis is a new and exciting computing paradigm with biological background. It involves the concepts ranging from Molecular Biology, Statistics to Computation while including theories and practices of computer science. Study in DNA Microarray includes the Gene Expression, Genetic Data Management, Repository system and the algorithms of image analysis. The aim of this review paper is to give an overview of the basic concepts of DNA Microarray based Genomic research, methodology and to discuss the pros and cons of some algorithms for cDNA Microarray image analysis. This paper is expected to benefit researchers and academics in Genomics.