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Handheld bio-impedance measurement system based on an instrument-on-chip

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4 Author(s)
Angelo Rottigni ; Dipartimento di Elettronica e Informazione, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Italy ; Marco Carminati ; Giorgio Ferrari ; Marco Sampietro

In this paper we present a compact system for impedance measurement in the kHz-MHz frequency range with attoFarad resolution. It has been designed to address micro- and nano-scale bio-sensing applications, such as impedimetric flow cytometry or molecular affinity bio-sensors. The core of the detection system is an integrated circuit that features a low noise current amplifier, a two-phase square waveform lock-in detector and two ΣΔ analog-to-digital converters. The CMOS chip is complemented by all the blocks needed to perform spectroscopy measurements, including versatile signal generation, digital processing and PC data transmission. The whole stand-alone system is USB powered and can reach sub-fF resolution in capacitive tracking on a sub-millisecond time scale.

Published in:

Ph.D. Research in Microelectronics and Electronics (PRIME), 2011 7th Conference on

Date of Conference:

3-7 July 2011