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Effects of Chrysanthemum morifolium on expressions of p53 and Bax in the Human Umbilical Vein Cells under Induction and Cultivation of high glucose

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2 Author(s)
Yinghui Liu ; Endocrinology Dept., Hangzhou Red Cross Hosp., Hangzhou, China ; Xin Mou

Objective : To discuss the effects of Chrysan them um morifolium on mRNA expressions of p53 and Bax in the Human Umbilical Vein Cells(HUVEC) under Induction and Cultivation of high glucose. Methods: Make four groups of the HUVEC as normal cells group, normal glucose only deal cells group high glucose -only deal cells group and Chrysanthemum morifolium + high glucose acting cells group. After 18~24h, the mRNA expressions of p53 and Bax were detected by reverse transcription-polymerase chain reaction (RT-PCR) method. Results: High glucose can up-regulation the mRNA expressions of p53 and Bax, and Chrysanthemum morifolium can decline the mRNA expressions of p53 and Bax in a dose-dependent manner,and the role of middle-dose is most manifest. Conclusion: Chrysanthemum morifolium can down-regulation the mRNA expressions of p53 and Bax, to prevent and cure diabetic vascular complications.

Published in:

Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on

Date of Conference:

24-26 June 2011