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The intra/extracellular beta-amyloid (Aβ) of neuron has been known as the most representative hallmark of Alzheimer's disease (AD). Recently, the clinical diagnosis of AD has been significantly issued with early detection of Aβ. For further accurate quantification of Aβ compared to current techniques, we suggest a new technical concept that enables the evaluation of as small as a few femtomolar Aβ peptide by using photo-sensitive field-effect transistor (p-FET) coated with selectively transmissible optical filter for a particular range of wavelengths of excitation beam. The photo-current generated by p-FET with arsenic trisulfide (As2S3) filter is as much apparent as about 76 nA for a small amount of Aβ-conjugated fluorescent particles. This result indicates that even with slightly small amount of Aβ peptides the As2S3 coated p-FET is applicable to recognizing optically tenuous fluorescence.
Date of Conference: 23-25 May 2011