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At the present time, fish disease information in Indonesia is limited and just documented partially in research reports, journals, and books. Otherwise, the latest and complete information about problem of fish disease were difficult to get by fish farmers, related agencies, and research groups. The limited dissemination of information on fish diseases had caused difficulties to controlling fish diseases in Indonesia. Therefore, it was needed to develop the computer programs or software to identify and controlling fish diseases in Indonesia. Software design method was using Based Reasoning Case (CBR). CBR scheme includes retrieve, reuse, revise, and retain. The retrieve stage of the cases used the nearest neighbor technique. This system has been built conceptually as basis for further programming development. By these methods, a variety of fish disease cases will be processed by computer systems based on similar cases that occurred formerly, and will be given the appropriate solution.