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Case for Applying Subnanosecond High-Intensity, Electrical Pulses to Biological Cells

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2 Author(s)
Joshi, R.P. ; Dept. of Electr. & Comput. Eng., Old Dominion Univ., Norfolk, VA, USA ; Qin Hu

In this paper, model analysis into the time-dependent transmembrane potential at the outer cell membrane is presented, for applied high-intensity electric pulses having durations in the nanosecond range or smaller. It is argued that the frequency-dependent dielectric response of cell membranes could be used to advantage for stronger bioeffects by employing shorter pulses. Our model calculations predict faster transmembrane voltages and larger electroporation densities for a given external energy with pulse durations in the subnanosecond regime. This temporal regime would be used, for example, in the electrotherapy of mixed cell ensembles having different dielectric response properties.

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Biomedical Engineering, IEEE Transactions on  (Volume:58 ,  Issue: 10 )